I was on Prednisone for 8 days because of a sinus headache that wouldn't go away. I was also put on amoxicillin for a possible sinus headache. I started on 60 mg for 2 days and than 40mg for 2 days , 20 mg for days and last 10mg for 2 days. The first day I took my headache became 10 times worse and I considered going to the ER. The second day I was suffering from muscle fatigue in my legs and my thighs burned. It also triggered my sciatica pain and pelvic pain caused by ovarian cysts and ovarian tumor. I believe it was the bloating that put more pressure on the sciatica and the cysts that caused the pain. It took a couple of weeks for the sciatica pain to subside, never really got rid of the pelvic pain. I am never ever taking Prednisone again, it has way too many side effects. Also, I think it caused a yeast infection.