I am a 56 yo male. I have been using albuterol for many years, especially at night to be ale to sleep through the night. In April 2007, my doc put me on Advair 250/50. Immediately, I was able to sleep through the night without using the Albuterol. Unfortunately, I also started to have trouble speaking. When I would speak, words would be cut off in the middle. In August, my doc sent me to a throat specialist to see if their were any physical problems. He found nothing wrong, but confirmed that the speech apnea was a possible side affect of Adavair. I stopped using it in the fall, and I have been able to speak normally since then. I have also only had to use the Albuterol twice since then. At least the Advair got me off the nightly use of the Albuterol