Aside from this drug not working as it should have in lowering my blood sugar, when my doctor increased my dosage it made me have headaches violent mood swings. One minute I was crying, the next I was extremely angry and the next I just didn't care about anything at all. I have no history of bi-polar disorder, but that was I experienced on this drug. I quit taking it and I'm perfectly fine now. My blood sugars are exactly as they were before it was prescribed.