I've been on Advair for 4 or 5 years and can never find a doctor who will even entertain the notion of taking me off of it. Although I have many symptoms that have been documented by GSK they consider it "very unlikely" that Advair is causing my joint pain, bloating, headaches, mouth sores etc. Last year I had pneumonia (also a reported adverse reaction) and THIS year I was diagnose with osteoporosis (yet another risk). I think these doctors are afraid that if they agree to wean me off & I die they'll get sued. Sorry to be so blunt but the problem is that the last doctor who tried to wean me off (now retired) even contacted the manufacturer & was told there is "currently no protocol" recommended for the cessation of Advair. My asthma got so bad when I tapered off, even with oral steroids he eventually just put me back on, hoping to hear of a protocol later. I'm very frustrated to say the least. Doctors seem to think "well it seems to be working since your still alive". Of course I can't to a certainty attribute all my symptoms to Advair it seems very unlikely that NONE of them are. Can't say if the Advair is directly causing depression but the Advair SITUATION is depressing!