My doctor gave me omnicef for a sinus infection and I must say that I felt much better before the I started the medicine. From the first day I had most of all the side effects, nausea, diarrhea, vomiting, no appetite, but no muscle/joint pain. However, since I finished the last pill, I have been experiencing extreme right leg pain in the hamstring area and below. Actually, my whole leg hurts like heck! I have been doing leg exercises and taking ibuprofen, but how long must I do this. It has been going on for 2 1/2 weeks now. I too will never take this medicine again. I am not even sure that it even helped my sinus situation, but if it did, it also caused way more problems than I had or ever expected.