When i was in college i was taking orthotrycyclin low, But stopped it for about to years just to clean out my system. Usually during my period (with no bc) last for one week and very heavy with pain. On top of that i only have one ovary. My doctor suggested that i should get back on some sort of bc to control my periods. I tried the patch but as soon as I placed the patch on my lower abdomen I had a migraine. (I've never had a migrane before). So I immediately was scared and took it off. I went straight to my dr. and he told me to try Loestrin 24. So I did. The first 2 months were not that bad. But recently I have been very moody especially when it comes close to that time of the month, I've felt much anxiety, and have been in and out of depression. Of course i've never had depression before but i come straight home from work and just feel down and like not doing anything. The other day I was busy with work and happened to miss my pill. Well ladies be sure not to miss a pill. I had severe cramps and spotting. I'm at the point that I want to get off of it and am really considering. I tried getting off of it before and realized that MY MOODINESS increased. Believe me my co-workers and boyfriend let me know. and my depression increased. I also gained about 15 lbs. since i've been on Loestrin 24. I consulted with my doctor and he said the bc's don't not make us gain weight. But after reading all these blogs i know I'm not the only one going through this dilemma....