am 45 year old male. For many years I have had chronic allergies and chronic sinusitis with headaches/migraines as a result. On two separate occasions I tried Singulair (two different doctors). Both times I experienced severe depression, thoughts of suicide, bed ridden for about 5-7 days and the headaches got much worse. Fortunately my wife is a psychiatric nurse and she recognized the side effects and got me off the Singulair. Within a week I was back to my normal self. On both occasions I talked to my doctors and they both had not heard of any side effects, such as depression. This evening I heard about Singulair on the news, which brought me to this web site, so I thought I would just share my experiences, nothing new, just another example. Singulair seems to be a very effective medication for someā¦but for a few of us it can be devastating, I would just say use with caution, and be aware of the side effects.