To be honest, both myself and both my kids have been on singulair for 10+ years and it has been a godsend blessing. My daughter was tested for CF -twice-as an infant before starting all the asthma meds, including singulair. My son is finally able to get off Advair but continues to take Singulair to keep off the other meds. ANY med can have side effects and not all meds are ment for all people. Some meds can cause severe reaction just from the binders used in the med or when combined with other meds. And in case you think I'm crazy and don't know about meds- My son is an EMT/Firefighter and I am an ICU nurse.