I was prescribed the Cipro, 250 for UTI....within 24 hours was having a headache which did go away within 3 days, cleared the UTI...made sure I took the Cipro with meals. Within 1 week of being off of the Cipro started having extreme stomach issues....burning, irritation.... took approx 2 more weeks taking Heartburn MD supplements with meals to "heal up" the stomach lining from the Cipro. Took Amoxicillin for past UTI's now the docs don't want to give Amox only Cipro. Was told by the doc that the UTI's have managed to build a resistance to the Amoxicillin.....I could understand that if you took Amoxicillin regularly. Hmmmm!