I took Adoxa for six months, and was so happy my skin cleared up, that it took me longer than it should have to come to terms with the other side effects. I took 200 mg/2x/day. I have experienced many, if not all of the things listed here: nausea, diarrhea, depression, all early on. I too stopped menstruating after several weeks of being on it. What has been more disturbing to me are the after-effects. I stopped taking Adoxa nearly two mos ago, and have been on hormones (progesterone, I am only 33) for the last several months to restore, but to no avail. I have had massive bloating, water retention, constipation, and my doctors believe they are all inter-related to taking this drug for so long. It has taken trips to countless doctors to even get to that conclusion. Unfortunately, I do not have a great solution for recovery. Has anyone else experienced this? My GI has had me taking Florastor (a probiotic, at any drugstore but you HAVE to ask for it-$40 and kept behind the counter) and thinks it will take at least another month to see benefit. My doctors said next they will treat for IBS but wanted to see if the effects would reverse themselves first.