It has been helpful to read all your posts. I really did think I was going crazy!!! I am so depressed and tired all the time. I have also gained 30lbs even though I eat healthy and exercise. I have been on Advair for 3 years and my life had gone down hill. Admittedly, my astma is under control. It seems like my systems have just gotten progressively worse over the years and now I have to decide between breathing and getting my life back. I am going to discuss with my Doctor and can't wait to hear what he has to say.