Have been on Zoloft for two years now. Taking 50mg daily. Recently I tried quiting cold turkey due to being fatigued all the time. Also because I was getting frustrated when every time I would get a prescription filled, they would give me 100mg pills that I would have to cut up.So in reality, I wasn't taking exactly 50mg every day. What a joke these insurance companies are to allow that. I also was able to get a 90 day prescription fill and now it has changed to 1 refill every 30 days due to my medical insurance changeing their policy on refills.What a mistake it was to quit cold turkey. After the 5th day of not taking zoloft I became a basket case. I started getting these brain zaps every so often, (feeling very numb at times). I have no choice now but to stay on this drug. Its like night and day when I don't take zoloft for more than a few days. I know now that I will be on this drug for the rest of my life. The down side for me is fatigue and decreased sexual desire but the pros heavily outweigh the cons. I will try decreasing my dosage from 50mg to 25mg daily to see if this will help my fatigue problem. Has anyone tried doing this? I truely believe that Zoloft has saved my marriage.