Both of my children are taking Singulair. My seven year old son has been on the drug for 3-4 years and we've noticed no problems. However, I am becoming very concerned about our three year old daughter. She was put on Singulair in November/December 2007 along with the other allergy medicines that she was already taking: Nasonex, Rynatan and Zyrtec. However, our allergist took her off the Rynatan and Zyrtec in mid-March and replaced them with Singulair. Since then, the child will not go to bed as she has in the past. She tosses and turns for an hour or hour an a half EVERY night. I've considered that maybe she needs to do away with the afternoon nap BUT she is still restless even if she hasn't had a nap that day. She is also doesn't want to get up in the mornings. We practically drag her out of the bed. This is very unlike her. She used to wake up easily every morning with a smile on her face and ready to go. Now she's a grump throughout the day and cries easily. My husband and I have decided to take her off the Singulair and see what happens. We already know that she is sensitive to some medications. We had an experience with Levalbuterol and Pulmicort (nebulizer treatments) in February that was scary. The pediatrician wanted her on the treatments 2X a day for 6 wks. The child was out of her mind on these meds. If someone had videotaped her and covered her face, I would not have know that it was my child. These meds. changed her entire personality. She took the treatments for 4-5 days and we decided enough was enough. As soon as we stopped the meds. she was back to her old self. She WILL NOT take them again unless there is absolutely no other alternative. I've decided that I've got to be more vigilant about watching for possible side effects of medications.