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I started taking two 160mg tablets of sulfameth a day about a wee...

Posted at 9:50 PM on Apr 09, 2008 by sulfadoom, #29395
I started taking two 160mg tablets of sulfameth a day about a week ago in conjunction with prednisone and hydroxyzine for a bad case of contact dermititis. Yesterday I woke up with a crazy fever, pressure in my sinuses and headache. I got off work and went to sleep at 5:30pm. Around 9pm I woke up covered in hives. The fever had broke, but this was a new beast. The hives started out all over, but there were not many. Over the next 24 hrs they spread so that now I am mostly a giant red splotch. It itches like hell and for some damn reason I feel wired. I can't get to sleep. I keep pacing around. I went to the ER and they said it was probably the sulfameth. They told me to discontinue use and put me on a higher dose of prednisone, zantac and diphenhydramine. I am almost sure it was the sulfameth. I have been on prednisone before without anything like this happening. I have never taken the sulfameth before this and I rarely took the hydroxyzine they gave me so I doubt it caused it. The reaction to the sulfameth is seriously 100 times worse then what they gave it to me for. I would rather have just not gone to the doctor and suffered through what I had before than deal with this. It's a sleepless, itching hell. I will never take a sulfa drug again. I can only wonder how bad it would have been had I not already been on prednisone when the allergic reaction hit. So 24 hrs into it and the hives are getting worse. Hopefully the prednisone and benadryl will end it soon.
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Reply 6 months ago on Apr 10, 2008 by sulfadoom, #6958

48 hrs later

I finally got to sleep for a little bit. The prednisone seems to have helped. My skin is still splotchy, but it looks like it is going away. I still itch, but it's tolerable. I can actually resist the urge to scratch it. I still feel wired. Like I am on a prolonged adrenaline dump. It's a strange feeling. I am tired as hell and fatigued, but on the other hand I am way more alert and awake then I should be for getting around 4hrs of sleep in 3 days.

What worked for me:
one 50mg tablet of prednisone a day for two days
two 25mg tablets of benadryl ever 4 hrs for two days
two 150mg tablets of zantac eq a day for two days

I still have to be on this stuff for a week more according to the perscriptions, but this was enough to stop most of the horrible symptoms. The prednisone is 50mg a day for 3 days and then taper down from there. The rest I will just keep taking at that dosage until I run out of the prednisone.

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This registry is a place to share positive or negative side effects of using Sulfamethoxazole. If you directly experienced a side effect while using Sulfamethoxazole, then we encourage you to enter it here. Please note that entries here are the experiences of individual users, and in no way means that you or anyone else will experience the same side effect, since the same medication affects people in different ways. Please always contact your physician.
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