I was Dx with Asthma in 98 after having bronchitis for the first time. I am not a smoker but Asthma does run in my family. I have been taking Advair 500/50 for 3 years and as far as controlling my Asthma I am so HAPPY to be on it!(I am 40 years old). In the begining I did struggle with side effects of heart burn,& tooth pain but that has subsided. The only side affect that has really affected my life is the loss of cartledge in both of my knee's. Granted I had a history of Femoral Patella Syndrome prior to taking ADvair, it just seems like the medicine has sped up the deteration. But Honestly. It has worked so well to control my Asthma, and nothin else seems to be stronger. I will have to choose breathing over my knee's.