Some of you who are following this site may remember that I poste...
| Posted at 10:36 AM on Apr 10, 2008 by concernedcitizen, #29408 |
Thanks for your research. I have been wondering about the genetic component to this since my son has neurological problems from birth and reacted to Singulair. I have a friend, her son has cerebral palsy, we both felt that our boys were affected because of their genetic make-up. I wonder what the connection is? Obviously this is not just affecting people with neurological disabilities, yet I wonder if the people who were affected were in some way genetically predisposed to things like depression, etc. With my son, the Singulair did not affect him right away, but rather once he began to have problems from a cyst in his brain. This leads me to believe that there were metabolic or chemical changes taking place as the cyst grew causing him to react to the Singular. He stayed on the Singulair for another year, suffering from many of the side effects listed on this site. He is now off the medication and doing very well. I wonder however what the effect of this will be on the developing mind of children. We need more information about the long term effects if there are any.
Again thanks for all your research.
" However, logically one might predict that it will be the combination of the polymorphisms in these different key regulatory enzymes and receptors that may ultimately determine treatment response. There have been some attempts to tease out the possible contribution of different genes important in this pathway for treatment response to a Cys leukotriene receptor 1 antagonist.18 However, because of the number of potential gene variants that may contribute to efficacy, large studies will be needed to fully evaluate the potential contribution of pharmacogenetic variability in this pathway to treatment response to Cys leukotriene receptor 1 antagonists. Work in the cardiovascular field has demonstrated the potential importance of genetic variants in this pathway to disease risk and also to treatment response,19 suggesting the potential for important effects to be defined in asthma."
When I saw that researchers acknowledged the number of potential gene variants that are involved in determining the efficacy of montelukast and then I am reading the reports of the side effects, I am wondering why montelukast was ever approved for seasonal allergies. Asthma is potentially life threatening but why take montelukast for annoying allergies that won't kill you.
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