A report from the Netherlands discusses depression. I had failed...

A report from the Netherlands discusses depression. I had failed to notice that the report stated that in three cases the onset of the depression after taking Singulair was from 3-14 days. Discussion and conclusion Lareb received four reports of depressive symptoms in patients using montelukast.Possible confounding includes that asthma itself has been associated with the development of depression [4]. Inhalated corticosteroids can also exert effects on the central nervous system. Fluticason in combination with salmeterol which is used by patients A, B and D, is associated with hyperactivity and irritability whereas budesonide, which is used by patient C also has been associated with depression [5,6]. ---------------------------------------------------------------------------------------------------------- The latency of montelukast-induced depressive symptoms varies from 3-14 days. ----------------------------------------------------------------------------------------------------------- In three of the cases a positive dechallenge was seen. The fact that the patients (except for one) did not suffer from depressive symptoms before they started montelukast, the short latency, and recovery after withdrawal of the drug all strengthen our hypothesis that depressive symptoms are an ADR related to the use of montelukast. According to the Marketing Authorisation Holder of montelukast, depression will be added to the product information.