I was on Minocin for acne for almost 2 years. It worked great. HOWEVER I started getting a stuffy nose that wouldn't go away. I went to ENT clinic for about 5 months trying to figure out what was wrong. Then I started getting so tired I could function or even to go to work. At this point I wasn't even thinking it could be the medicine since I had been on it so long. I started having days when the joints in my fingers would stiffen and my knees, hips would stiffen. There were times I could hardly walk. Then my rosecea would flare up really bad. Each place on my body where I had a scar, there would be a perfect round circle around it that would itch. One point they had dx me with cat scratch fever! Symptoms continued and got worse. I was having tightness in chest, shortness of breath and the joint pain would come and go. I was tested for lupus and received a "false postive" reading. At that point I started doing my own research and found out that some meds will cause a drug induced type of lupus. I stopped the med and symptoms went away. They put me on doxycycline and immediately I started getting a stuffy nose and my joints would ache. I can no longer take any meds that are in the "cycline" family. However, I just thougt it odd that I could be on a medicine for 2 years before I had any type of reaction.