I have taken Prednisone several times for allergic reactions.The main side effects I have encountered are 1.Shakiness 2. mood swings 3. anxiety-mild depression 4.upset stomach 5 rapid heartbeat.6.insominia. To counteract the anxiety, moodines, insomnia I take benadryl. I talked to my pharmacist and she said Benadryl is ok to take with Prednisone- you should still talk to your Doctor or Pharmacist. The Benadryl takes some of the edge off of the prednisone. As for the upset stomach I just make sure I eat before I take the Prednisone.