I first started Effexor 6 years ago I tried coming off it twice,the 1st was a nightmare but took the 2nd time real slow.Trouble is I had to go back on it as its the only one that has worked for me and my doc says i might be on them for life!Its either have a crap life of take something that helps the quality of my life and effexor is the only thing,and I take 225mg's a day.Its made me put on 3-4 stone and took my sex drive away also had to give up booze as it sent me loopy with the effexor.Going to have a review soon with a new psychiatrist so will see.