Yes, I gained weight, but I'm in my mid thirties, so I figured I was just getting older, metabolism slowing & all that, but my doctor began reducing my dose from 200 - 150. Good God! Such a small reduction, but I had explosive anger issues and I couldn't well contain my emotions. An ad in a magazine got me crying and I couldn't stop! I finally ended up with tremors and had to leave work. I didn't consider myself psychotic before. I took Seroquel for sleep and as a mood stabilizer. I always took it at night. Now I have been exhibiting some kind of psychoses. I hope my body is adjusting. Sometimes I only took 100 mg, saving the other 50 mg for emergencies. Can't do that anymore. Besides asking the doctor to increase my dose back to 200 mg, what can I do?