It is scary to read everyone's posts on this drug. I also had two shots of Kenalog within the past 3 months for a problem in my cervical spine. I had mild side effects from the first shot, but since the second one, the side effects have gotten more severe. I've gained 15 lbs (and I've been on a strict diet so there's no reason to have gained that weight). Also, after the second shot I had absolutely excruciating joint pain in my knees and ankles, my face is puffy, I have a hump on my back in between my shoulders, my resting heart rate is up at about 108, and I have random stretch marks on my thighs. I believe that all of these side effects are from the Kenalog because I've always been very healthy and in excellent shape and have never had health problems until now. My dr. did all kinds of blood tests and an EKG and everything came back normal, which also tells me the problems are from the drug. This shot was the biggest mistake of my life! My dr. is still insisting that my problems aren't from the shot and he wanted to do a third injection. I said ABSOLUTELY NO! I went and got a second opinion, and my new dr. said that all of these side effects are from the massive amounts of Kenalog that was pumped into my spine and I'm on a new treatment plan. I am against these types of injections. It has caused me more harm then good.