I'm a 48 year old male in good physical condition and not overweight. I have genetic high cholesterol and started taking Zocor about 3 years ago. My cholesterol had climbed to 280 before I started the statin. I started with 5mg but my doctor quickly raised it to 10mg. After 6 weeks my cholesterol was down to 180! Yippee! The only side effects I noticed at first was swollen eyelids in the morning. After about 18 months my cholesterol had climbed to about 225 so my doctor raised the dose to 20mg. About 3 months later I started getting abdominal pain and tightness in my chest. My doctor thought I had gallbladder problems, I had an ultrasound which was negative. The pain(s) continued and I had blood tests, 2 MRI's, chest Xray and EKG... all negative. I suggested quiting the Zocor but my doctor didn't think that was the problem. I decided to quit the statin 1 week ago. Not feeling much better yet, but I will post an update.