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Some common sense observations about Singulair side effects. (As...

Posted at 12:14 PM on Apr 29, 2008 by concernedcitizen, #30020
Some common sense observations about Singulair side effects. (As everything on the internet, this is only my opinion.) Conclusion up front: Ethics in science SUCKS these day. Put enough money on the table and what happens? I don’t mean all scientists, just the few. But, the Merck ghost writers are the tip of the iceberg for those in the schm#ck category. Maybe, if we reveal the extremes of abuse of laboratory animals, the ASPCA will organize and save us all. How about if they find out about the pharma labs that just beat the cr@p out of the lab animals to produce a stress response to find out what chemicals are produced? What was that all about?? Probably military—send our soldiers out to war over politics/oil, then we will have a pill to give them every night to put them back together again for the next day?? 1.The cysLT1 receptor, which Singulair blocks, is a gene, found on the x chromosome (?), part of our inherited innate immune system. It is evolution. The hypersensitive individual overreacts to environmental stimuli causing unpleasant or dangerous symptoms. It is advantageous to intervene to prevent that. Merck’s idea was to block cysLT1 so that the chemicals secreted by the mast cell cannot reach the tissues in the lungs and nasal passages to cause the inflammatory responses-asthma being the more severe. 2.How did Merck develop such a drug? The cysLT1 receptor , a gene, has a profile, a chemical map of the components. Montelukast, was modeled to chemically bond with the receptor so that it does not function. That bond will endure until the liver enzymes break it down. Montelukast blocks the leukotriene response until it is time to take another pill. All that sounds good so far. 3.Now comes the first of the too good to be trues. Montelukast was formulated for a specific gene profile. However, cysLT1 has variations, numbers unknown, but more than several. Even Merck recognizes that it is not effective for everyone because the clinical data shows that. Mis-matches with the gene profile can cause montelukast to be recognized as an allergen. Then, the body mounts an immune response against montelukast. 4.Many of the symptoms that we see here are allergic reactions to montelukast, headache (18%), types of neuro-muscular (10%), hives, nausea, vomiting, leg pain, stomach cramps, and more. Some people will recognize montelukast instantly as an allergen. If the mis-match is slight, the allergic reaction could be acquired or build over time. Montelukast will ALWAYS be an allergen to those people. Doctors will do great harm if they treat allergic reaction to montelukast with other drugs. Those people must STOP taking montelukast. 5.The second too good to be true, is that cystLT1 receptor, involved in the leukotriene response, is only a very tiny part of the immune system, genetically programmed to function as a WHOLE. Now what? It is highly unlikely that montelukast can block the leukotriene receptor - cysLT1 in the brain, lungs, spleen, intestinal mucosa, etc. and not cause some kind of re-structuring of the immune system to compensate for that. Those who take Singulair can expect that they are a new adaptation of human being who can operate without the cysLT1 receptor. Or, they can expect long term damage. How scary is that? 6.What would happen if Merck revealed that montelukast, by definition , cannot work for everybody because it is based on a gene profile with variations? What would happen if patients and doctors started to think about the immune system as a whole? Then Singulair – which means “single thing you need for air – breathe” the logo is even Singul-AIR, would not be the huge money maker that it is. Doctors would find a way to use it, for whom it is effective, in an appropriate way to consider the long term effects. For some people, this drug could have a place. But this drug does not deserve to be a CASH COW-money, money, money! 7.What in the heck is wrong with the FDA? Are they under a spell or hiding under a rock?
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Reply 4 months ago on Apr 29, 2008 by kacie1, #7765

I have been reading your many posts but recently have been too busy to keep up. Have you found any literature to suggest that the damage is reversible? I have a 10 year old on it for 6 years. She became suicidal, hearing voices telling her to take a knife and kill herself. Since removing Singulair she hasn't had the hallucinations but is daily battling anxiety. Any ideas as to a way to speed the exit of Singluair from the system. She has been off it and in Psychotherapy about 6 weeks. I am outraged that I poisoned my child and want answers. I reported my case to the FDA. 'typical of doctors they have denied any correlation.

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Reply 4 months ago on Apr 30, 2008 by concernedcitizen, #7771

I did have one idea. Omega-3 fatty acids are reported to have a positive effect on the brain. There have been quite a few studies. So I would concentrate on very good nutrition, avoid known allergens, and get lots of sleep. Maybe eat more foods high in omega-3.

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Reply 4 months ago on May 02, 2008 by concernedcitizen, #7881

Here is the story about the Pentagon. Pentagon, Big Pharm Drug Troops to Numb Them to Horrors of War. I heard the story about the lab animals from a friend.

http://www.alternet.org/healthwellness/72956/?page=1

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