I'm a 40 year old female with severe asthma (since I was about 4). I have taken more meds in my life than I can count and nothing has worked like Advair Diskus 500/50. I absolutely LOVE this stuff (so far). I have been taking it 2x a day for two months and no longer need any other meds, not even my inhaler which I always used as my security blanket. I have also had major skin issues since childhood and my skin is now softer and smoother than ever. I don't have any weight gain issues, sore throat, cough, headaches, etc., but I am noticing that lately my body feels TIRED and my legs feel crampy at times, mostly when I wake up after a full night's sleep. I really think this med is well worth it for me, but maybe not for all. Is everyone here rinsing their mouth out after each use? Maybe that is the cause of the sore throat side effect. I wish everyone good health!