Does montelukast affect growth in children? Remember the report ...

Does montelukast affect growth in children? Remember the report of identical twins, one took Singulair and one didn't. If I remember correctly, the one who took Singulair was at least two inches shorter in a short period of time. If anyone would like a reason to look into that, then I refer you to this study. It could suggest that leukotrienes act on the pituitary to release pituitary hormones. We don't know what happens when the production of leukotrienes are blocked by montelukast. "Finally, leukotrienes have also been found to act on the pituitary to modulate the release of the pituitary hormones." "The distribution data of HPN321 suggests major role(s) for this receptor in endocrine and cardiovascular systems. CysLTs are well known for their modulatory effects in cardiovascular functions, where they reduce myocardial contractility and coronary blood flow (Letts and Piper, 1982) and have vasoactive effects (Drazen et al., 1980). They are thus considered to be important players in cardiovascular diseases (for review, see Folco et al., 2000). The strong expression of HPN321 in adrenal gland points at a new tissue where to study the influence of CysLTs on endocrine circuits. Finally, leukotrienes have also been found to act on the pituitary to modulate the release of the pituitary hormones (Hulting et al., 1984; Saadi et al., 1990). Our discovery of the existence of the HPN321 message in pituitary adds a molecular credence to this concept. The HPN321 receptor may thus modulate a variety of different physiological functions, which can now be tested using BAY u9773." Vol. 58, Issue 6, 1601-1608, December 2000 ACCELERATED COMMUNICATION Molecular Cloning and Characterization of a Second Human Cysteinyl Leukotriene Receptor: Discovery of a Subtype Selective Agonist Hans-Peter Nothacker, Zhiwei Wang, Yuhong Zhu, Rainer K. Reinscheid, Steven H. S. Lin, and Olivier Civelli Departments of Pharmacology (H.P.N., Z.W., Y.Z., R.K.R., S.H.S.L., O.C.) and Developmental and Cell Biology (O.C.), University of California at Irvine, Irvine, California; and NeoGene Technologies, Inc., Irvine, CA (H.P.N., Z.W., R.K.R., O.C.) http://molpharm.aspetjournals.org/cgi/content/full/58/6/1601