Generally begin to experience relief from sinus infections after 5 doses, nearly 24 hours' worth (of 250mg 3X daily). Amoxicillin typically exacerbates viral/fungal type symptoms that occur when I have any kind of infection or lowered resistance (two or three small pimples on tip of nose, itchy scalp, mild tinea pedis between 4th and 5th toes which I never get otherwise, and slight flaring of a nearly invisible planter's wart which I've had since I was a teen. Amoxicillin also provokes a mild depression similar to pms symptoms, potential weepiness if provoked, and, in the last two years (perhaps because I may be--at 51-- approaching menopause), hot flashes. Because I can develop extremely serious sinus and/or impacted sinus infections, I'm glad for various antibiotics (1-3 times annually), but I can't say that I always like the side affects.