Was fine for the first two months...a little spotting/some breakthrough bleeding, but nothing really awful. About three months in, I began experiencing terrible anxiety with such terrible panic attacks that I was pretty incapacitated as a mother (my poor little kids). My periods began starting the week before they "actually" started...you could call it "breakthrough" bleeding, but it was really a full-on bleed with lots of clotting, back pain, and cramps so bad I felt like I was having contractions. Most recently has been the nausea, I've actually lost weight because I've hardly been able to eat for weeks (thought it might be morning sickness---yikes!--but luckily my fun 2.5 week period began, painfully, yesterday so I'm in the clear). I didn't realize these things were all related to Desogen until I reread the package...it's pretty clear that the pills are the reason. I'll be switching pills next month at my annual appt.