I took one pill on the day the Doctor prescribed them for a urinary tract infection, and had severe leg cramping to the point where I could not walk, lay, or move without major pain. I couldn't have anything touch my legs without being in agony. It lasted hours. Likewise, several days after, I have tingling in both hands when sleeping at night.
I stopped taking it immediately. Last year, I also had a urinary tract infection, and forgot the name of the antibiotic I was prescribed, but believe it is the same as this time which is SMZ-TMP DS, and had the same leg cramping and tingling in my hands, but at first did not know it was a side effect of the medication. So, I suffered through severe leg cramps, and tingling hands for days until I finally called the Doctor, and he said it was strange but was an allergic reaction.
I've had frequent urinary tract infections throughout my life, and never had an issue with antibiotics prescribed up until this one came along. I think it's dangerous and needs to be re-evaluated.