I didn't realize how many problems this med has caused for other people as well. I've been on Minocin for acne and Cipro for prostates in the past and never had any major side effects until taking Doxycycline. I've been on it for two weeks and have two more left for a prostate infection. My latest is an aching pain in my lower legs and tingling in my feet and toes. My main advice for this med would be 1) Take with a decent sized meal and 2) DO NOT lie down for at least one hour after taking or it could irritate your esophagus. I took it before bed the first couple of days and had some bad heartburn for a couple of days but it is gone for the most part now. I've also had the tightness in the face, throat, and chest. My advice there is to relax and take some deep breaths to eliminate any anxiety that could make it worse. If it doesn't go away or gets worse and you have trouble breathing or anything like that you may be having an allergic reaction. I'm definitely going to have a talk with my doctor for not warning me about all of these side effects before putting me on this crap for a month.