I have been on prednisone for one week for poison ivy and I cannot get more than one or two hours of sleep a night. I have taken sleep aids, benadryl, phenergan and nothing is working. My skin still iches like crazy even though the poison ivy is gone. I also have substantial mood changes. I am extremely laid back and nothing bothers me. My company lost their entire customer database and orders and my response was "sucks to be you" normally I would be stressed and trying to fix it. I also drank while on prednisone because the bottle didn't warn against it. I don't think I need to explain how stupid I made myself look. Does anyone know how long it takes for this stuff to wear off?