First time taking Prednisone, I was prescribed for an injured rotator cuff. All it took for me was one 20mg pill before bed. I only slept for about an hour and a half in that time i experienced extremely vivid nightmares i then woke up for the rest of the night with bouts of paranoia. for some reason i thought i needed to have my gun under my pillow, i kept thinking someone was going to break in my house.(this is not typical behavior for me) Stoped use of the pills immediately.