I have been taking a low dose of zoloft (25mg) daily for about 9 months now and it has helped with my peri-menopause symptoms. I was having anger issues and depression associated with the changing hormones. I have never had these problems before recently so that is why they put me on the zoloft. It has helped a lot but the side effects have caused me to request a change in medication. I have some mild problems with diarrhea and headaches but nothing too bad. The worse one is the total lack of sex drive. I have no use for sex at all any longer. What is worse is that even if I do it for my husband it is impossible for me to have an orgasm or even become aroused. Strange. Hopefully there is something else out there that will help without this bothersome side effect.