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decomposition of lisinopril in acidic medium so narrow absorption...

Posted at 7:13 AM on May 30, 2008 by ravindrasemwal, #30941
decomposition of lisinopril in acidic medium so narrow absorption window.
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Reply 5 months ago on Jun 11, 2008 by ravindrasemwal, #9102

Call your doctor at once if you have any of these serious side effects:

feeling light-headed, fainting;

urinating more or less than usual, or not at all;

fever, chills, body aches, flu symptoms;

tired feeling, muscle weakness, and pounding or uneven heartbeats;

chest pain; or

swelling, rapid weight gain.

Less serious side effects may be more likely to occur, such as:

cough;

dizziness, drowsiness, headache;

nausea, vomiting, diarrhea, upset stomach; or

mild skin itching or rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome

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Reply 5 months ago on Jun 11, 2008 by ravindrasemwal, #9104

It has been observed in the literature that therapeutically effective polypeptides (aan) with two or more amino acids (n≧2) are poorly absorbed orally. Even a polypeptide of as few as two amino acids, or related structures, exhibits very narrow absorption windows and poor bioavailability. As an example, the Physician's Desk Reference (PDR) reports that the angiotensin converting enzyme (ACE) inhibitor Enalaprilat (R1-Ala-Pro; n=2) is very poorly absorbed orally. Enalapril (R2-Ala-Pro), which is a pro-drug of Enalaprilat, is better absorbed orally, but the end result demonstrates only a 25% relative bioavailability of the active moiety (Enalaprilat) released from in vivo cleavage of the prodrug. In comparison, Lisinopril (R3-Lys-Pro) has relatively good solubility in water, but only a moderate oral bioavailability

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Reply 5 months ago on Jun 20, 2008 by tita313, #9356

When you stated that decomposition of Lisinopril in acidic medium is narrow window - does that mean that because I have GERD, then this can cause my burning sensation on my tongue & throat?

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