I have had this shot 4 times now for severe seasonal allergies and asthma (1 shot per year). I did have one side effect, heartburn. So I took zantac for the heartburn. Otherwise, I have had immense relief from the allergies/asthma from this shot. I am concerned about what I am reading on this website though, so I will think twice before getting the shot again. The nurse who gave me the shot seems quite experienced and she is the same nurse that has given the shot every year. I did have to sign some forms about the risks of taking the shot.