My dermatologist recommended and gave me a sample of Neutrogena Healthy Defense SPF 45 after I had a treatment for a pre cancerous spot on my nose. I first purchased the SPF 30 as the SPF 45 was not available. I used the SPF 45 sample and the SPF 30 for two weeks with no problems. I then found the Neutrogena Healthy Denfense SPF 45 with helioplex and purchased it. Within two days of use I broke out in a horrible itchy, burning, red rash with watery looking bumps and dry skin all over my face and neck where the helioplex had been applied. I do not have sensitive skin and have never experienced this reaction to any other product. I reported this reaction to my dermatologist who recommended I discontinue use of the SPF 45 (duh!). I am on day three of the rash and it has not diminished although some of the bumps have scabbed over. I saw no warning on the packaging of side effects. I agree that the helioplex needs to be researched for these side effects and the consumer needs to informed.