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My 54-year-old fit, social, successful husband was put on Singula...

Posted at 8:30 PM on Jun 06, 2008 by celticmoon, #31158
My 54-year-old fit, social, successful husband was put on Singulair in January for newly diagnosed asthma. He developed a depression with anxiety, irrational fears, avoidance, mood swings and even one episode of suicidal thoughts out of nowhere. He saw a psychiatrist and a therapist, tried medications, yoga, a vacation, meditation, breathing exercises - everything! But he kept getting worse. The day he was throwing patio furniture then sobbing uncontrollably was the day he realized he couldn't work in his condition. He negotiated a 60-day leave without pay. Even that didn't help. It was crazy. How could a man who managed hundreds of employees and a major health service system for 20 years suddenly be so paralyzed with fear that he couldn't walk down a beach or go into a Walgreen’s? We found this site May 26th. He stopped the Singulair immediately. It has been 10 days and he is already 80-90% back to normal. Thank God. Partly I am writing because it is so hard to read of parents' guilt that they "should have known" etc. Look, unlike a child, my husband is mature and very verbal; he is also a psychiatrist (!) with a capacity for self-examination and a language to describe his inner experience. And me, I'm a psychologist (!) trained in understanding people and I know him very well. And yet with all that training and skill and consultation and treatment, WE STILL COULDN’T FIGURE THIS OUT! So please, don't make yourself feel any worse with guilt. This is awful and tragic enough already. I would add that the onset of mood and behavioral problems is so insidious that it is hard to connect the problems to the Singulair. Also, I suspect that children and adolescents are at greater risk because of their immature emotional developmental level. An adult l suspect may need some genetic or personal predisposition to mood disturbance, or stress, or both, to trigger these side effects. My husband had a depression episode 30 years ago and had recent traumas that certainly could have triggered the depression. But how treatment resistant that depression was, and those strange paralyzing fears and extreme anxiety – all that I blame squarely on the Singulair. I have made a report to the FDA. I urge you to do the same.
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Reply about 1 year ago on Jun 07, 2008 by flindy, #9003

So glad you found this site,yes the effects are subtle,yes we have seen an improvment in our children since taking them off,and yet the doctors still have tunnel vision, what will it take.This drug is under investigation for suicide and yet a few postings up we see a major peds hospital prescribe it for a one yr old.How in gods name does a one yr old tell you they are suicidle.I have never felt so frustrated and helpless in my life.The kids that were on it long term and are now off show an improvement of 80% or more ,then why is nobody concerned about the remaining effects,my doc wouldnt even ask my son what was different in his thinking.I could just scream,It took all i had in me not to cause a confrontation,but my son was with me so i chose not to but just look for a different doc

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Reply about 1 year ago on Jun 07, 2008 by concernedcitizen, #9014

Many researchers believed that Vioxx was changed by ionization caused by physiological events. The structure of montelukast would be sensitive to change in physiological pH to the acid side of the equation. The fact that many complain of adverse neuro-psychiatric side effects meants that something is happening that causes neuro-toxins.

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Reply about 1 year ago on Jun 10, 2008 by massmomof3, #9088

Do you know how it might be possible to alert the psychiatric community about Singulair? I told my son's psychiatrist that I was quite sure Singulair explained most of his symptoms. At first he seemed curious to learn this, but a week or so later when I asked him to send his records to our pediatrician (so she could report to the FDA) he told me my theory was "controversial." I think it would be great for someone with your (and your husband's) background to help spread the word. I hope your husband is doing well. Good luck!

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Reply about 1 year ago on Jun 11, 2008 by memphisrn, #9112

Thank you for your post. My daughter saw a psychiatrist who was clueless when I told her about the FDA investigation in late March. On the other hand, her allergist knew it and said it my daughter was not the only one so severely impacted.
I want her year back in life, the first year of college, gone. She is so upset by failing and now I have to build her self-esteem back. On the bright side, she has only been off for 6 days, and she is singing, laughing, and happy already! It is amazing, esp. since I told her it would take a few months, this is real! I had extra guilt, not only am I a nurse, I am a certified clinical research coordinator. I know I am very careful and might have noted this. Too many PI's are hiring people to work on their studies without any medical background. I hope your husband is back out there to help us get the word out with you. Thank you again.

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