I have been reading research reports that show that montelukast (...

I have been reading research reports that show that montelukast (Singulair) has a higher pKa than many of the other quinoline malaria drugs. That means that Singulair ionizes more easily than even drugs that are known to cause terrible dreams, hallucinations, depression, anxiety, and suicidal thoughts. Many researchers believed that the problem with Vioxx was that it ionized under certain physiological conditions. I will report again when I can confirm the numbers. I am not sure if it is confirmed that montelukast's pKa is around 5.8 and the malaria drugs is around 4.8. I need to do more work before I can point out that it is not impossible to theorize that montelukast ionizes like Vioxx.