I am about 1.5 years after my lupron shots and I still have sever joint pain and muscle aches, i feel slower in the brain and get mad at my self for not performing up to par like I used to. My knees feel like they want to explode or crumble when i walk up a set of stairs. All this stared and continued after the lupron. I feel very weak and wonder if it will ever go away or what I can do to make it better. If I knew then what I know now I would have never taken the shots. Good Luck out there.