My dosage has been 250/50 and I have been using the medication for about 3 years. I have experienced increased mucus, hoarseness, and thrush. I now have the thrush under control by thoroughly rinsing my mouth after using the inhaler. The hoarseness was not caused directly by the Advair, rather it was caused by frequently clearing my throat due to the mucus. My wife is a speech language pathologist and noticed my frequent throat clearing and explained that throat clearing irritates the vocal chords and causes hoarseness. By avoiding harsh throat clearing the hoarseness has gone away. I still have issues with thick mucus but it is minor nuisance compared with the improvements to my breathing.