My brother has been on Asacol for about 2 years, since initially being diagnosed with ulcerative colitis. He started to bleed again about 1.5 months ago and his physician recommended he go on a Lialda study. He has not stopped bleeding since switching to Lialda from Asacol and soon developed pneumonia. I am not saying that the pneumonia is a side effect of the Lialda, but it is secondary to the reduced immunity from the slow and continuous bleeding. He also has what is called "dumping syndrome" where as soon as you eat a couple mouthfuls, you cannot eat anymore and have to wait a while. He also is extremely tired, mostly due to the anemia, and has very loose bowel movements, up to 3-5 times just in the morning hours. He has skin rashes that won't resolve even with prescription ointment. His ulcerative colitis seems to be exacerbated as well. One thing we are countering a lot of his symptoms with is holistic treatments, namely good diet and acupuncture.