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I started full body internal itching after taking 10 days of Sing...

Posted at 11:10 PM on Jun 22, 2008 by debp, #31649
I started full body internal itching after taking 10 days of Singulair. The physician that prescribed it said it couldn't cause itching. My new doctor tested for Lupus, I have an autoimmune disorder called Churg Strauss. After undergoing several steroid treatments and 3 days of IV Prednisone I got some relief. This has been going on for 6 months now. The itching becomes severe enough to make me want to commit suicide. Luckily it is pretty controlled by taking nightly doses of Atarax along with Periactin. Thank God I found a doctor who cared enough to search out the symptoms and help me get thru day by day.
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Reply 3 months ago on Jun 23, 2008 by cheflette, #9415

did you have your C-S diagnosis before or after you started singulair?

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Reply 3 months ago on Jun 23, 2008 by concernedcitizen, #9421

: Ned Tijdschr Geneeskd. 2008 Mar 1;152(9):513-7.Links

Gielen CL, van't Wout JW.
A 75-year-old woman with a history of asthma, rhinitis and nasal polyps was admitted due to petechial lesions on the lower left leg and weakness of the right foot. Six weeks prior to admission, she had started treatment with montelukast 10 mg daily. Based on the asthma, eosinophilia, mononeuritis of the right leg and a skin biopsy showing small vessel vasculitis with eosinophilic granulocytes, the patient was diagnosed with Churg-Strauss syndrome (CSS). After consulting with the pulmonologist, montelukast therapy was discontinued and replaced with a combined preparation of a parasympatholytic and a P2-sympathomimetic. The patient was also given prednisone 60 mg daily, which resulted in prompt clinical improvement and resolution of the eosinophilia. Development of CSS has been associated with the use of montelukast and should be considered in patients with asthma who develop new symptoms, such as neuritis, vasculitis of the skin or pulmonary infiltrates with an increase in eosinophilia during montelukast therapy. In these patients, treatment with montelukast should be discontinued, although whether a causal relationship exists between montelukast and CSS continues to be debated in the literature.

PMID: 18389887

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