I find some of these posts interesting because it seems as if some folks either do not completely read the dosing instructions that come with all medications when they are picked up from a pharmacy or given by a doctor, or they just choose to ignore them. I have been on Doxy for six months for the treatment of Lyme and Rocky Mountain Spotted Fever. It's been no picnic at times but I feel 100 times better than before I started it. When I started taking Doxy, I too didn't pay much attention to the dosing instructions and I learned the hard way with some uncomfortable side-effects. Here are a few recommendations from someone who has been taking this drug long-term. 1. You must eat! Eat a small snack (banana, crackers, fruit) before you take the drug. Do not take it with something that you know upsets your stomach, also do not take it with dairy or any supplements containing magnesium or iron. 2. After taking the drug, eat another small snack, same as in #1. Avoid any of the supplements or dairy listed above for at least two hours. 3. Imperative!!! Take a good probiotic regularly (30-50 billion cfu). Antibiotics are designed to kill stuff in your body. They do not distinguish between bad and good however. You need the probiotic to replace the good bacteria in your digestive tract, otherwise your body will not digest properly. I was constipated for quite some time before I figured this one out. 4. I saw a few other folks mention this one. Do not lay down immediately following taking the drug. Again, I learned the hard way, I had severe GERD for a time as well. 5. Avoid long-term sun exposure. This was the latest. My skin has always had some natural pigmentation in it for a white guy and I have not burned too easily. On the Doxy though, I found out that I burn extremely fast. I guess I will be under an umbrella at the beach in a few weeks. 6. Don't panic! This drug was made to fight infections/disease. Be prepared for some side-effects, but also don't be afraid to see your doctor if they are just unbearable. All people do not respond to medications in the same manner. What works for you or me might not work for someone else. I hope this information helps someone out there. I know it is incredibly frustrating when you are taking something to cure an illness and more things go wrong.