These posts have certainly raised some questions in my mind. I am a 48 female, w/mild to moderate COPD - chronic bronchitis due to years of smoking. I have been taking Advair for about 8 years. I have joint and muscle pain all the time, clearing of throat constantly, hoarse like voice, poor urine stream, red eyes, blurry vision. I've had depression and anxiety attacks for years so I can't really blame that on Advair. I take 250/50 strength once a day. I cannot take the second dose in the evenings. If I do, I will not sleep. I go to my pulmonary doctor next week and will definitely talk to him about other options and coming off Advair.