I took my first dose of Niaspan last night and it will be my last. A few hours after taking it I started to feel tingling and itching in my feet and legs. Suddenly I started having a nauseated pressure in my chest and then the firey itching started. My face and body felt like it was swelling so badly that it hurt move. I tried cold wash cloths but it didn't help. I had to sit up in bed to be able to breath right. I was in tears. I had a similar reaction when I took codiene and never took that again. I work in a emergency room and it is hard for me to get upset or scared about things, but this scared me. I finally was ablet o fall asleep a couple of hours later.