I have been on Advair for about 5 years. I started with the 100/50 dosage and i guess it wasn't working for me so I was switched to the 250/50. I am 5'6' and I use to weigh about 150lbs. Now after 5years I weight almost 200lbs. I have been experiencing major leg pain that just started a year ago, and I have no idea where it came from. I thought my weight gain was due to birth control, but I stopped taking that a while ago. now after reading all of these comments I think that the Advair was the cause of all of it. I just got married last May and I weight about 165, I have not been exercising like I should, but I don't eat a lot of bad foods. I have gained over 30lbs since then. I went to the doctor about a week ago before i read all of these comments and ordered a 3 month supply of Advair. I think Im just going to stop taking it all together. I would rather take my albuterol more often than have people asking me every six months am I pregnant because my face looks fatter.