I was prescribed Bactrim for 10 days. On about the 7th/8th days, I noticed my lymph nodes under my jaw were becoming very painful and swollen. By the next night my lymph nodes continued to become more swollen and painful under my jaw and spread all along under my jaw and in my neck (I looked like I had two chins!). I also then developed a fever of 102, chills, severe headache and ached all over (oh yeah, my heart was racing for days). The fever and chills made me absolutely miserable! I could barely get out of bed or off the couch for almost 4 days. The next morning after fever, chills, headache, I woke up with a red, splotchy, sunburn-like rash from my neck to my ankles, which got itchier and more painful in the next two days. My MD said the rash was a reaction to Bactrim but did not seem to know what the other symptoms were from so ordered blood tests and told me he was "concerned" for me (I was freaking out)! The bloodwork came back negative (thank God). He still didn't seem to put the other symptoms with the rash and Bactrim. I then started to research Bactrim allergies/side effects online and found this website. I found that others had experienced some of the same horrible side effects as I had. It was pretty scary until I realized this was all apparently related to Bactrim, as my MD apparently had no clue. Other's experiences helped validate what I was experiencing so thanks to you all who shared your Bactrim horror stories! I started feeling a little better 48 hours after the last Bactrim dose and at about 72 hours, I pretty much felt back to normal. No more Sulfa for me!