I have been on Wellbutrin XL for several years now and it has been the most effective for me of all the antidepressants I have tried. My husband went to pick up my refill and they inadvertently substituted the Budeprion XL. Although he questioned the pharmacist, they assured him there was no difference. I finally gave in and decided to give it a try 4 days ago and each day I get more and more depressed, irritable, unmotivated, and lethargic. I had been consuming a lot more caffeine just to keep going. I keep telling my husband that I just do not feel right and the Budeprion XL does not work as well. Until I read all these experiences, I began to think I was imaging it or I was just cycling. Now, I am fairly certain that it is a result of the ineffectiveness of the Budeprion XL. This is the end of the road for Budeprion XL and me.