I was diagnosed with endometriosis in 2007. I had the surgery, and then started the shots. I suffered depression during my 6 months of the Lupron shots. Not too bad, but I didn't feel like myself. Kind of emotionless. I had no motivation to do anything. I have no history of depression. When I got off the shots, it got worse. I had terrible panic attacks to the point where I felt paralyzed. It was awful! My Doctor never told me that it was a possible side effect of the shots and the progesterone pills I was on. I found that out when I started researching myself. I am now seeing a counselor, because it was really scary to feel that way. I am doing much better, but I will never take Lupron again. I found out that going from no hormones at all (on Lupron) to all of a sudden having a period again can really screw with you. It can cause a chemical imbalance. While I was on Lupron, I also had headaches, terrible hot flashes, night sweats, achne, and gained about 18 pounds....not fun! Good luck to all of you taking this medication. Just keep a good relationship with your doctor. I went in to this with no information. If I would have been more informed, the outcome could have been different for me.