Have been on Seroquel 300mg for about a month now for management of bipolar. Was combined with Depakote, but the doc discontinued the Depakote. With Seroquel *only*.... Works great for getting to sleep, but. significant weight gain (like 12lbs in 30 days), dry/cotton mouth almost like dehydration, fatigue from simple tasks, mentally foggy during the daytime, loss of emotion, poor motor skills/reaction time, and restless legs. The foggy feeling I attribute to a long half-life with a residual effect carry over to the next day. Before this med, I was manic, but now into a mild emotionless depression which is a dreadful feeling. Saw my doctor today, and he said
to cut the dose to 150mg and said it is a wimpy dose. In my opinion, this
is a horrible maintenance drug for bipolar.